SARMs Cycling

This article is a brief introduction on how to dose SARMs including post cycle therapy and frequently asked questions regarding taking them.

Ostarine/Enobosarm

Developed by GTx and Merck. Ostarine is a potent SARM that was used for treatment of muscle wasting diseases.

Half-life: 24 hours

Pros and cons:

  • Versatile, good for maintaining muscle mass, strength and fat-loss.
  • Resistant to the enzyme, aromatase so little chance of unwanted estrogen = no man boobs!
  • Good for recovery from injury and tendon damage due to its ability to increase the efficiency of collagen synthesis.
  • Testosterone suppression is a risk at longer cycles (>12 weeks) and higher doses (>30mg).
  • Acne
  • Headaches

What is a sensible dosage of Ostarine?

Between 10mg and 30mg – anymore and you’re not only risking suppression but diminishing returns.

Example cycles

Simple, lean gains

6 week cycle – starting at 10mg and working up to 15mg by week 3 and continuing until the end of the cycle.

Bulking

8 week cycle – starting at 20mg and working up to 30mg by week 4 and continuing until week 6 and then reducing to 20mg and then again to 10mg by week 8.

Cutting with Ostarine

12 week cycle – starting at 10mg and continuing until the end of the cycle.

 

Andarine/S-4

Developed by GTx for muscle wasting symptoms associated with certain diseases.

Half-life: 24 hours

Pros and cons:

  • Good for lean mass gains or cutting
  • Drying effect of the muscles, giving a ripped look.
  • Resistant to the enzyme, aromatase so little chance of unwanted estrogen = no man boobs from this either!
  • Not as potent as Ostarine which means it’s more manageable in terms of effects on the body
  • Suppressive but not as bad as Ostarine.
  • Cycles must be strictly managed*
  • Vision problems may occur (see below)
  • Acne

What is a sensible dosage of Andarine?

Between 10mg and 50mg – anymore and you’re likely to encounter serious vision problems such as a yellow tint, loss of night vision and ultra-sensitivity to light.

Example cycles

Simple, lean gains with Andarine

8 week cycle – starting at 25mg and building up to 50mg by week 4 and continuing to the end of the cycle.

Cutting on Andarine

12 week cycle – starting at 10mg and building up to 25mg by week 4 and continuing to the end of the cycle.

*Due to the nature of Andarine, it’s best to follow a 5 days on, 2 days off rule during each week of a cycle to minimise risk of vision impairment.

 

RAD 140

Developed by Radius Health for treatment of muscle wasting disorders. Good for lean muscle gains.

Half-life: 24-36 hours

Pros and cons:

  • Good for lean mass gains
  • Great anabolic effect
  • Fewer androgenic side effects
  • Very suppressive

What is a sensible dosage of RAD 140?

Between 5mg and 20mg – anymore and you’re likely to risk complete testosterone shutdown.

Simple, lean gains

2x 2 weeks on and 2 weeks off – 10mg continuously

Bulking

4x 2 weeks on and 2 weeks off – 20mg continuously

 

LGD-4033

Developed by Viking Therapeutics as a promising treatment of muscle wasting disorders.

Half-life: 36 hours

  • Good for lean mass gains
  • Few side effects
  • Suppressive but very manageable for most people
  • Very potent
  • Acne
  • Low libido

What is a sensible dosage of LGD-4033?

Between 1mg and 4mg – anymore and you’re not likely to see any exponential returns so it’s not worth the testosterone shutdown risk.

How long should you cycle?

Simple, lean gains

4 weeks on, then 4 weeks off – starting off at 1mg in week 1 and building up to 2mg by week 4.

Bulking

9 weeks on, then 9 weeks off – starting off at 1mg in week 1 and building up to 4mg by week 4. At week 6, reduce to 3mg and then to 2mg and back to 1mg by week 9.

Cutting or fat loss

12 weeks on, then 12 weeks off – starting at 1mg in week 1 and building up to 2mg by week 4, continuing at 2mg until week 10 and reducing to 1mg by week 11.

SARM on SARM stacking

Taking multiple SARMs during one cycle is unnecessary. They all have almost identical functions and similar side effects but with different potencies. The only thing you’re doing by stacking them is risking even more.

sarms faqs

Should I take them with food or on an empty stomach?

Either is fine, there’s no documented evidence to suggest that a full stomach negates any effects.

 

What length is the average cycle?

5 – 8 weeks.

 

Do I need milk thistle or any supplements to protect the liver?

All of the SARMs included in this article are not methylated and so are non-toxic to the liver.

When’s the best time to take SARMs?

It doesn’t matter too much. Although it’s best to try take them at the same time every day to ensure levels remain stable.

Will I need PCT? (Post Cycle Therapy)

Due to the suppressive nature of SARMs, you may want to consider implementing PCT to elevate your testosterone levels back up. Though it’s not absolutely necessary.

 

This very crude table below is based on a survey of 52 males aged 16-55. “Low dosage” assumes you’re taking the lower end of the suggested dosage and “high dosage” assumes you’re taking the higher end of the suggested dosage found at the top of this article.

 

Age 21 – 25 26 – 30 31 – 35 35 – 40 40 – 45 50+
Cycle Length
4-6 weeks low dosage No No No Probably Yes Yes
4-6 weeks high dosage No No Probably Probably Yes Yes
6-8 weeks low dosage No No Probably Yes Yes Yes
6-8 weeks high dosage No Probably Yes Yes Yes Yes
8-12 weeks low dosage No Probably Yes Yes Yes Yes
8-12 weeks high dosage Probably Yes Yes Yes Yes Yes

 

The need to implement PCT varies by age and context. If you stick to the dosages above then you may experience some slight suppression but your body should naturally recover.

Make sure to take the same number of weeks off as you do on. E.g. if you do an 8 week cycle, take 8 weeks off to recover.

For cycles of more than 12 weeks it’s recommended to have PCT in place and ready unless you’re prepared to wait 12 weeks for your body to recover naturally.

Higher dosages will more than likely cause suppression and potentially result in shutdown. Stick to the recommended dosages outlined in this article and you should be okay.

What PCT do you recommend?

If you are going to do PCT then you must use something that can stimulate your HPTA, such as a Selective Estrogen Receptor Modulator (SERMs). If you can get a hold of SARMs you can get a hold of SERMs such as Nolvadex/Clomid.

I’m new to PCT, any suggestions on what to do?

To retain those gains, PCT should be implemented when androgen levels begin to drop. Levels should drop roughly at the time when the original value reaches half (half-life). Depending on the cycle length, you may need Nolvadex and Clomid – if you stick to the dosages in this article then Clomid should be enough.

Ostarine – 24 hours

Andarine – 24 hours

RAD 140 – 24-36 hours

LGD-4033 – 36 hours

An example of PCT may look like this for a 12-week Ostarine cycle:

Clomid – 100mg on day one then 50mg thereafter for the following 10 days.

More SARMs will be added as research continues – why not read more about SARMs here.